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It acts as a probiotic, therefore it contributes to having a healthier and more diverse microbiota, since it increases the number of bifidobacteria, thereby preventing infections and improving the functioning of the immune system.
- Newborns and infants: It can be found in high concentrations in colostrum and later in lower concentrations in breast milk. The function of this molecule, among other things, is to contribute to the formation of a healthy microbiota and to the maturation of the intestinal epithelium, since it induces the growth and proliferation of enterocytes, thereby reducing the permeability of the intestine. If a child is not breastfed, it is suggested to supplement with a formula added with lactoferrin.
- Cancer Prevention: It has been shown to have anti-tumor properties in vivo and in vitro, since it induces cytotoxicity, reduces invasion and migration in tumor cell cultures. It also induces apoptosis of cancer cells. The models that have been studied and that have positive effects are colon, esophageal, lung and breast cancer. Oral lactoferrin has been shown to have synergistic effects with traditional chemotherapy.
- Anti-Allergic Activity: It inhibits allergic reactions, among others, by the uptake of iron and the inhibition of the expression of the inflammatory mediators TNF-alpha, IL-1-beta, IL-6 and IL8. Lactoferrin significantly reduces the allergic reaction caused by pollen.
- Antioxidant Activity: Lactoferrin is a non-enzymatic antioxidant. Via the chelation of iron from body fluids and infected areas, lactoferrin counteracts iron-induced oxidative stress and protects cells against irreparable oxidative damage and apopotosis.sis.